English
norskBlar i forfatter "Bjerkli, Inger-Heidi"
Viser treff 1-12 av 12
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Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-16)<i>Objectives</i> - Incidence of oral cavity squamous cell carcinomas is rising worldwide, and population characterization is important to follow for future trends. The aim of this retrospective study was to present a large cohort of primary oral cavity squamous cell carcinoma from all four health regions of Norway, with descriptive clinicopathological characteristics and five-year survival ... -
Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the ... -
Combined loss of expression of involucrin and cytokeratin13 is associated with poor prognosis in squamous cellcarcinoma of mobile tongue.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)Background - This study aimed to evaluate the prognostic significance of expression levels of involucrin (IVL), cytokeratin (CK)-10 and -13 at different intratumor sites (tumor center and invading area) of oral tongue squamous cell carcinoma (OTSCC).<p> <p>Methods - IVL, CK13 and CK10 expression levels were examined in a multicenter cohort of 146 OTSCCs using immunohistochemistry. External mRNA ... -
Evaluation Challenges in the validation of B7-H3 as oral tongue cancer prognosticator
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)B7-H3 was the only molecule identified with prognostic potential from a recent systematic review of the prognostic value of immune checkpoints in oral cancer. We aimed to validate this finding in a multicenter international cohort. We retrospectively retrieved 323 oral tongue squamous cell carcinoma (OTSCC) samples from three different countries (Brazil, Finland, and Norway) for immunostaining and ... -
Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-03)<i>Background</i> - Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring system should be robust and well validated, and intra‐ and interrater agreement can be used as a tool to visualize the strength of reproducibility.<p><p> <i>Methods</i> ... -
High-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)<p><i>Objectives - </i>The presence of and the causative role of high‐risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high‐risk HPV ... -
The Practically Wise Medical Teacher: Medical Education at the University of Tromsø – A Norwegian Case
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-19)This article addresses the issue of teaching quality in medical education and investigates what characterizes a professionally competent or practically wise medical teacher through the use of longitudinal data from interviews with 40 medical students. In discussing the findings, Aristotle’s concepts of episteme, techne and phronesis, and theoretical perspectives on professionalism and quality in ... -
Prognostic indicators of survival for patients with oral cavity squamous cell carcinoma in Norway. Outcomes in a retrospective, multicenter cohort, with special focus on oral tongue squamous cell carcinoma, 2005-2009
(Doctoral thesis; Doktorgradsavhandling, 2020-10-08)Oral cavity cancer (OCC) is the most frequent of head and neck cancers, most being squamous cell carcinomas (SCC). Within the oral cavity, the oral tongue is the most common site of cancer. These cancers are very aggressive, with poor survival. The treatment decision is based upon classifications of tumor (T), lymph node (N), and metastasis (M), although tumors with the same classification may act ... -
The prognostic role of combining Krüppel-like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor involved in inflammation, cancer development, and progression. However, the relationship between KLF4, inflammation, and prognosis in oral cancer is not fully understood. KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. ... -
Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-25)<i>Background</i> - The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of invasion. We also assessed the prognostic impact of the 8th edition of the American Joint Committee on Cancer’s TNM classification (TNM8), where ... -
Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-14)The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral ...
